Footrot is a serious disease in sheep that causes severe economic loss, suffering due to lameness and disruption to normal farm operations.
In a Meat & Livestock Australia (MLA) funded collaborative research project between Monash University and the University of Sydney, reverse vaccinology, an approach successfully applied in human medicine, was employed to identify five potential footrot vaccine antigen candidates.
MLA Program Manager Health Welfare & Biosecurity, Dr Johann Schröder, said one of the problems with conventional footrot vaccines is that there are 10 variants of the major protective antigen.
"That means if you vaccinate against one strain of the bacterium that causes footrot, it doesn't protect the sheep against the other nine. What...